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Comprehensive Overview of Flavonoids: Antioxidants and Anticancer Agents

Flavonoid Antioxidants
Flavonoids, found abundantly in fruits, vegetables, and plant-based beverages, are powerful antioxidants known for their potential health benefits. These polyphenolic compounds exhibit significant antioxidant properties in vitro, but their in vivo roles are not entirely understood. Research is ongoing to determine how flavonoids are absorbed, metabolized, and circulated in the body, and how these processes affect their antioxidant activities. Their ability to reduce oxidative stress may protect against cellular aging and contribute to redox regulation in cells. Understanding the bioavailability and metabolic transformations of flavonoids is crucial to unlocking their full potential as antioxidants.

Flavonoids as Anticancer Agents
Flavonoids also possess promising anticancer properties, making them a significant focus of cancer research. These compounds can modulate reactive oxygen species (ROS) scavenging enzyme activities, arrest the cell cycle, and induce apoptosis and autophagy in cancer cells. They act as antioxidants under normal conditions and as pro-oxidants in cancer cells, triggering apoptotic pathways and downregulating pro-inflammatory signaling. Flavonoids' dual action regarding ROS homeostasis highlights their potential as both preventative and therapeutic agents in cancer treatment. Their wide-ranging effects on cellular processes underscore the need for further research into their mechanisms of action and bioavailability.

Summary
Flavonoids are versatile compounds with significant antioxidant and anticancer properties. They play a crucial role in reducing oxidative stress, regulating redox states in cells, and inhibiting cancer cell proliferation. Ongoing research aims to fully understand their absorption, metabolism, and bioactivity in vivo, paving the way for potential dietary recommendations and therapeutic applications.

Sources: https://pubmed.ncbi.nlm.nih.gov/11375750/
https://pubmed.ncbi.nlm.nih.gov/11375750/